Past Research

RecA protein assures fidelity of DNA repair and genome stability in Deinococcus radiodurans.

RecA protein assures fidelity of DNA repair and genome stability in Deinococcus radiodurans.
Deinococcus radiodurans is one of the most radiation-resistant organisms known. It can repair hundreds of radiation-induced double-strand DNA breaks without loss of viability. Genome reassembly in heavily irradiated D. radiodurans is considered to be an error-free process since no genome rearrangements were detected after post-irradiation repair. Here, we describe for the first time conditions that frequently cause erroneous chromosomal assemblies.

Protein damage and death by radiation in Escherichia coli and Deinococcus radiodurans.

Protein damage and death by radiation in Escherichia coli and Deinococcus radiodurans.
Deinococcus radiodurans is among a small number of bacterial species that are extremely resistant to ionizing radiation, UV light, toxic chemicals, and desiccation. We measured proteome oxidation (i.e., protein carbonylation, PC) in D. radiodurans as well as in standard and evolved resistant strains of Escherichia coli exposed to ionizing radiation or UVC light and found a consistent correlation with cell killing. The unique quantitative relationship between incurred PC and cell death holds over the entire range of killing for all tested bacteria and for both lethal agents, meaning that both bacterial species are equally sensitive to PC.

Unstructured hydrophilic sequences in prokaryotic proteomes correlate with dehydration tolerance and host association.

Unstructured hydrophilic sequences in prokaryotic proteomes correlate with dehydration tolerance and host association.
Here, we explore possible hallmarks of prokaryotic desiccation tolerance in their proteomes. The content of unstructured, low complexity (LC) regions was analyzed in a total of 460 bacterial and archaeal proteomes. It appears that species endowed with proteomes abundant in unstructured hydrophilic LC regions are desiccation-tolerant or sporulating bacteria, halophilic archaea and bacteria, or host-associated species.

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Nothing in life is to be feared, it is only to be understood. Now is the time to understand more, so that we may fear less.

- Marie Curie -

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Biological responses to DNA damage

 

 

 

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Miroslav Radman - Molecular Biology and Genetics Scientist