Recent Research

L’horloge de la vie

L’horloge de la vie
Je fais l’hypothèse qu’elle repose sur des modifications chimiques des protéines, modifications produites, pour l’essentiel, par oxydation, laquelle altérerait son fonctionnement. Le vieillissement et les maladies qui l’accompagnent seraient les conséquences phénotypiques progressives de l’accumulation du dégât oxydatif ainsi causé aux protéines au cours de la vie. Je discuterai également ici de la prévention des maladies « incurables » liées au vieillissement.

Research at MedILS (Mediterranean Institute for Life Sciences): Scientific Vision and Projects

Research at MedILS (Mediterranean Institute for Life Sciences): Scientific Vision and Projects
Scientific Vision and Projects by cofounders Miroslav Radman and Ivan Matic, March 2015.

Epigenetics of Aging

Epigenetics of Aging
Miroslav Radman, 20/02/2015 Prelude to new project: If the most upstream cause of aging is oxidative protein damage, then oxidative damage to the system of DNA methylation maintenance may be the root cause of cell-transmissible changes in DNA methylation patterns. We need to find out if such epigenetic change is subject to reversion by means other than cell reprogramming.

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Greatest quotes

There are in fact two things, science and opinion; the former begets knowledge, the latter ignorance.

- Hippocrates -

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Past Research

RecA protein assures fidelity of DNA repair and genome stability in Deinococcus radiodurans.

RecA protein assures fidelity of DNA repair and genome stability in Deinococcus radiodurans.

Deinococcus radiodurans is one of the most radiation-resistant organisms known. It can repair hundreds of radiation-induced double-strand DNA breaks without loss of viability. Genome reassembly in heavily irradiated D. radiodurans is considered to be an error-free process since no genome rearrangements were detected after post-irradiation repair. Here, we describe for the first time conditions that frequently cause erroneous chromosomal assemblies.

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Protein damage and death by radiation in Escherichia coli and Deinococcus radiodurans.

Protein damage and death by radiation in Escherichia coli and Deinococcus radiodurans.

Deinococcus radiodurans is among a small number of bacterial species that are extremely resistant to ionizing radiation, UV light, toxic chemicals, and desiccation. We measured proteome oxidation (i.e., protein carbonylation, PC) in D. radiodurans as well as in standard and evolved resistant strains of Escherichia coli exposed to ionizing radiation or UVC light and found a consistent correlation with cell killing. The unique quantitative relationship between incurred PC and cell death holds over the entire range of killing for all tested bacteria and for both lethal agents, meaning that both bacterial species are equally sensitive to PC.

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Unstructured hydrophilic sequences in prokaryotic proteomes correlate with dehydration tolerance and host association.

Unstructured hydrophilic sequences in prokaryotic proteomes correlate with dehydration tolerance and host association.

Here, we explore possible hallmarks of prokaryotic desiccation tolerance in their proteomes. The content of unstructured, low complexity (LC) regions was analyzed in a total of 460 bacterial and archaeal proteomes. It appears that species endowed with proteomes abundant in unstructured hydrophilic LC regions are desiccation-tolerant or sporulating bacteria, halophilic archaea and bacteria, or host-associated species.

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Biological responses to DNA damage

Biological responses to DNA damage

DNA Repair Systems and Bacterial Evolution - Book Biological responses to DNA damage; page 11 - 19.

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in the BOOK: SOS Hypothesis and the Emergence of Integrative Biology

in the BOOK: SOS Hypothesis and the Emergence of Integrative Biology

A major discovery can often be recognized by the need to coin a new word (e.g., atom, radioactivity, antibiotic, apoptosis, etc). If the discovered entity or phenomenon does not have its cognate word in our vocabulary, it is surely a breakthrough. Coining the word SOS response (SOS system, SOS replication, SOS repair) to describe coordinated multiple inducible cellular responses to DNA damage resulting in induced mutagenesis and cell survival, was such a privilege (Radman 1974). This is a personal historical account of the intellectual circumstances that led to the birth of SOS hypothesis

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Miroslav Radman - Molecular Biology and Genetics Scientist