Volume 151, Issue 2, March 2000, Pages 91–95

Evolution-driving genes

  • Miroslav Radman,
  • François Taddei,
  • Ivan Matic
  • Faculté de médecine Necker-Enfants malades, Inserm E9916, université Paris-V, 156, rue de Vaugirard, 75730 Paris cedex 15, France



Genomic sequences provide evidence for a common origin of life and its evolution via selection of genetic variants created by mutation and recombination. Two classes of genes are known to accelerate mutation and/or recombination rates in bacterial populations: stress-inducible wild-type genes, usually part of the SOS regulon, and genes whose functional loss, or downregulation, increases the rate of genetic variability (mutator and/or hyper-rec mutants).


  • evolution;
  • genomic sequence;
  • mutation;
  • recombination



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